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The differentially spliced mouse tagL gene, homolog of tag7/PGRP gene family in mammals and Drosophila, can recognize gram-positive and gram-negative bacterial cell wall independently of T phage lysozyme homology domain

  1. Author:
    Kibardin, A. V.
    Mirkina, II
    Baranova, E. V.
    Zakeyeva, I. R.
    Georgiev, G. P.
    Kiselev, S. L.

  2. Author Address

    Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia NCI, Mol Immunoregulat Lab, Div Basic Sci, Frederick, MD 21702 USA Kiselev SL Russian Acad Sci, Inst Gene Biol, Moscow 119334, Russia
    1. Year: 2003
  2. Journal: Journal of Molecular Biology
    1. 326
    2. 2
    3. Pages: 467-474
  4. Type of Article: Article
  1. Abstract:

    Tag7/PGRP, a recently characterized antimicrobial protein, is conserved from insects to mammals. Recently its involvement in Toll signalling in Drosophila was demonstrated. A number of genes representing a new family homologous to PGRP were identified in Drosophila and human. Here we describe a splicing pattern of the tagL gene, mouse member of tag7/PGRP family. Some of the identified splice variants lacked characteristics for the family T phage lysozyme homology domain (also known as PGRP domain). Accordingly to the predicted transmembrane domains, mouse TagL may be secreted as inducible proteins or retained on intracellular membranes. All detected splice variant isoforms of TagL bound Gram-positive, Gram-negative bacteria and peptidoglycan. This binding did not depend on the presence of T phage lysozyme homology domain but was associated with the C-terminal portion of the polypeptides. Thus, this variety of isoforms of a single gene may play a role in circulating bacteria recognition in mammals. (C) 2003 Elsevier Science Ltd. All rights reserved.

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