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Total synthesis of (+/-)-rhazinal, an alkaloidal spindle toxin from Kopsia teoi

  1. Author:
    Banwell, M. G.
    Edwards, A. J.
    Jolliffe, K. A.
    Smith, J. A.
    Hamel, E.
    Verdier-Pinard, P.

  2. Author Address

    Australian Natl Univ, Inst Adv Studies, Res Sch Chem, Canberra, ACT 0200, Australia Australian Natl Univ, Inst Adv Studies, Res Sch Chem, Canberra, ACT 0200, Australia Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia NCI, Div Canc Treatment & Diagnosis, NIH, Screening Technol Branch,Dev Therapeut Program, Frederick, MD 21702 USA Banwell MG Australian Natl Univ, Inst Adv Studies, Res Sch Chem, Canberra, ACT 0200, Australia
    1. Year: 2003
  2. Journal: Organic & Biomolecular Chemistry
    1. 1
    2. 2
    3. Pages: 296-305
  4. Type of Article: Article
  1. Abstract:

    The title alkaloid I and its B-nor-congener 3, both of which display potent and unusual anti-mitotic properties, have been synthesized in racemic form and characterised by single-crystal X-ray analysis.

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