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Killer-cell immunoglobulin-like receptor (KIR) nomenclature report, 2002

  1. Author:
    Marsh, S. G. E.
    Parham, P.
    Dupont, B.
    Geraghty, D. E.
    Trowsdale, J.
    Middleton, D.
    Vilches, C.
    Carrington, M.
    Witt, C.
    Guethlein, L. A.
    Shilling, H.
    Garcia, C. A.
    Hsu, K. C.
    Wain, H.

  2. Author Address

    Royal Free Hosp, Anthony Nolan Res Inst, Pond St, London NW3 2QG, England Royal Free Hosp, Anthony Nolan Res Inst, London NW3 2QG, England Stanford Univ, Sch Med, Stanford, CA 94305 USA Sloan Kettering Inst Canc Res, New York, NY USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA Univ Cambridge, Cambridge, England No Ireland Tissue Typing Lab, Belfast, Antrim, North Ireland Hosp Puerta Hierro, Madrid, Spain Frederick Canc Res & Dev Ctr, Frederick, MD USA Royal Perth Hosp, Perth, WA, Australia Univ Washington, Seattle, WA 98195 USA Anthony Nolan Res Inst, London, England Univ Coll London, HUGO Gene Nomenclature Comm, London, England Marsh SGE Royal Free Hosp, Anthony Nolan Res Inst, Pond St, London NW3 2QG, England
    1. Year: 2003
  2. Journal: Immunogenetics
    1. 55
    2. 4
    3. Pages: 220-226
  4. Type of Article: Article
  1. Abstract:

    During discussion at the WHO Nomenclature Committee for Factors of the HLA System meeting in Victoria, Canada in May 2002, it was decided to form a subcommittee to co-ordinate the naming of alleles of the genes encoding the killer-cell immunoglobulin- like receptors KIR) (Marsh et al. 2002). These genes are encoded on chromosome 19 (19q13.4) and have varying degrees of polymorphism. The receptors encoded by the KIR genes are expressed by natural killer (NK) cells and a subset of T cells and some of them have been shown to have specificity for determinants of HLA class I molecules. The extracellular ligand-binding part of KIR consists of two or three immunoglobulin-( Ig-) like domains. The discussions which took place in Victoria are further to earlier discussions on KIR nomenclature at the NK Polymorphism meeting ( 27 - 29 July 2001) in Cambridge, UK. In addition a request has been made by the International Union of Immunological Societies (IUIS) to provide a standardised nomenclature for the expressed protein products of the KIR genes.

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