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Susceptibility of human T cell leukemia virus type I to nucleoside reverse transcriptase inhibitors

  1. Author:
    Hill, S. A.
    Lloyd, P. A.
    McDonald, S.
    Wykoff, J.
    Derse, D.
  2. Author Address

    Natl Canc Inst, Basic Res Lab, Canc Res Ctr, Frederick, MD 21702 USA Natl Canc Inst, Basic Res Lab, Canc Res Ctr, Frederick, MD 21702 USA Natl Canc Inst, Sci Applicat Int Corp, Frederick, MD USA Derse D Natl Canc Inst, Basic Res Lab, Canc Res Ctr, Frederick, MD 21702 USA
    1. Year: 2003
  1. Journal: Journal of Infectious Diseases
    1. 188
    2. 3
    3. Pages: 424-427
  2. Type of Article: Article
  1. Abstract:

    A single-cycle infection assay with recombinant viral vectors was developed to study human T cell leukemia virus type I (HTLV-I) replication and its inhibition by antiviral agents. The susceptibility of HTLV-I to 6 nucleoside reverse- transcriptase inhibitors was examined. HTLV-I replication was inhibited by tenofovir, abacavir, lamivudine, zalcitabine, stavudine, and zidovudine.

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