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The role of lymphotoxin in development and maintenance of secondary lymphoid tissues

  1. Author:
    Tumanov, A. V.
    Kuprash, D. V.
    Nedospasov, S. A.

  2. Author Address

    Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia NCI, BRP, SAIC Frederick, Frederick, MD 21702 USA Nedospasov SA Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia
    1. Year: 2003
  2. Journal: Cytokine & Growth Factor Reviews
    1. 14
    2. 3-4
    3. Pages: 275-288
  4. Type of Article: Review
  1. Abstract:

    Secondary lymphoid organs provide the necessary microenvironment for the cooperation of antigen-specific T- and B-lymphocytes and antigen-presenting cells in order to initiate an efficient immune response. Remarkable progress in understanding of the mechanisms of lymphoid organogenesis was achieved due to the analysis of various gene-targeted mice. This review primarily focuses on the role of lymphotoxin (LT) in development, maturation and maintenance of secondary lymphoid organs. Published by Elsevier Science Ltd.

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