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Heterogeneity in Rates of Recombination in the 6-Mb Region Telomeric to the Human Major Histocompatibility Complex

  1. Author:
    Malfroy, L.
    Roth, M. P.
    Carrington, M.
    Borot, N.
    Volz, A.
    Ziegler, A.
    Coppin, H.

  2. Author Address

    Roth MP CHU PURPAN CNRS UPR 8291 CTR IMMUNOPATHOL & GENET HUMAINE F-31300 TOULOUSE FRANCE CHU PURPAN CNRS UPR 8291 CTR IMMUNOPATHOL & GENET HUMAINE F-31300 TOULOUSE FRANCE NCI FREDERICK CANC RES & DEV CTR BIOL CARCINOGENESIS & DEV PROGRAM SAIC FREDERICK FREDERICK, MD 21702 USA HUMBOLDT UNIV BERLIN KLINIKUM RUDOLF VIRCHOW INST EXPT ONKOL & TRANSPLANTAT MED D-14050 BERLIN GERMANY
    1. Year: 1997
  2. Journal: Genomics
    1. 43
    2. 2
    3. Pages: 226-231
  4. Type of Article: Article
  1. Abstract:

    Analysis of 784 informative meioses in the CEPH pedigrees revealed a total of 22 recombination events having occurred in the 6-Mb region between D6S265 (70 kb centromeric of HLA-A) and D6S276. These 22 breakpoints were localized with respect to anonymous polymorphic markers, leading to a detailed genetic map of the region telomeric to the human major histocompatibility complex. A nonrandom pattern of recombination was observed throughout this region: the low recombination rate of 0.19% within the 4-Mb interval centromeric to the HLA class I-like candidate gene for hemochromatosis indeed contrasts with the approximate 1% rate observed within the most telomeric two megabases. This reduced rate of recombination may be due to selective constraints depending on environmental factors related to immunity and iron status or to structural variations hampering proper meiotic pairing of homologous sequences. Population data from other human genome segments are now needed to determine whether linkage disequilibrium extending over 4 Mb is unique to this region. (C) 1997 Academic Press. [References: 21]

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