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Studying cancer families to identify kidney cancer genes

  1. Author:
    Zbar, B.
    Klausner, R.
    Linehan, W. M.

  2. Author Address

    NCI, Immunobiol Lab, Canc Res Ctr, Frederick, MD 21702 USA NCI, Immunobiol Lab, Canc Res Ctr, Frederick, MD 21702 USA NCI, Ctr Canc Res, Urol Oncol Branch, Bethesda, MD 20894 USA Zbar B NCI, Immunobiol Lab, Canc Res Ctr, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Annual Review of Medicine-Selected Topics in the Clinical Sciences
    1. 54
    2. Pages: 217-233
  4. Type of Article: Review
  1. Abstract:

    We studied families with multiple members affected with renal cancer to delineate clinically distinct forms of inherited renal cancer, and to identify and characterize the genes responsible for these disorders. Today, cancer geneticists recognize seven clinically distinct, inherited forms of epithelial renal cancer; genes responsible for five inherited predispositions have been found. Positional cloning efforts for one kidney cancer gene are nearing completion. These discoveries will provide diagnostic tests for these diseases, a foundation for studies of the relationship between genotype and phenotype, and a basis for studies of the pathophysiology of the diverse types of epithelial renal cancer.

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