Skip NavigationSkip to Content
Return Return to Search Results

Hematopoietic, angiogenic and eye defects in Meis1 mutant animals

  1. Author:
    Hisa, T.
    Spence, S. E.
    Rachel, R. A.
    Fujita, M.
    Nakamura, T.
    Ward, J. M.
    Devor-Henneman, D. E.
    Saiki, Y.
    Kutsuna, H.
    Tessarollo, L.
    Jenkins, N. A.
    Copeland, N. G.

  2. Author Address

    Copeland, NG, NCI, Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD 21702 USA NCI, Ctr Canc Res, Mouse Canc Genet Program, Frederick, MD 21702 USA. Japanese Fdn Canc Res, Inst Canc, Tokyo 170, Japan. NCI, Ctr Canc Res, Vet & Tumor Pathol Sect, Frederick, MD 21701 USA. Osaka City Univ, Sch Med, Dept Hematol, Osaka 545, Japan.
    1. Year: 2004
  2. Journal: Embo Journal
    1. 23
    2. 2
    3. Pages: 450-459
  4. Type of Article: Article
  1. Abstract:

    Meis1 and Hoxa9 expression is upregulated by retroviral integration in murine myeloid leukemias and in human leukemias carrying MLL translocations. Both genes also cooperate to induce leukemia in a mouse leukemia acceleration assay, which can be explained, in part, by their physical interaction with each other as well as the PBX family of homeodomain proteins. Here we show that Meis1-deficient embryos have partially duplicated retinas and smaller lenses than normal. They also fail to produce megakaryocytes, display extensive hemorrhaging, and die by embryonic day 14.5. In addition, Meis1-deficient embryos lack well-formed capillaries, although larger blood vessels are normal. Definitive myeloerythroid lineages are present in the mutant embryos, but the total numbers of colony-forming cells are dramatically reduced. Mutant fetal liver cells also fail to radioprotect lethally irradiated animals and they compete poorly in repopulation assays even though they can repopulate all hematopoietic lineages. These and other studies showing that Meis1 is expressed at high levels in hematopoietic stem cells (HSCs) suggest that Meis1 may also be required for the proliferation/self-renewal of the HSC

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel