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Caulibugulones A-F, novel cytotoxic isoquinoline quinones and iminoquinones from the marine bryozoan Caulibugula intermis

  1. Author:
    Milanowski, D. J.
    Gustafson, K. R.
    Kelley, J. A.
    McMahon, J. B.

  2. Author Address

    Gustafson, KR, NCI, Ctr Canc Res, Mol Targets Dev Program, Bldg 1052,Room 121, Frederick, MD 21702 USA NCI, Ctr Canc Res, Mol Targets Dev Program, Frederick, MD 21702 USA. NCI, Ctr Canc Res, Med Chem Lab, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Journal of Natural Products
    1. 67
    2. 1
    3. Pages: 70-73
  4. Type of Article: Article
  1. Abstract:

    An extract of the marine bryozoan Caulibugula intermis, collected in the Indo-Pacific off Palau, produced a distinct pattern of differential cytotoxicity in the National Cancer Institute's 60 cell line antitumor screen. Bioactivity-directed fractionation of the extract provided six new compounds, caulibugulones A-F (1-6). The structures of these novel metabolites were determined by spectrochemical analyses including LC-MS, HRFABMS, 1-D and 2-D NMR experiments, and by comparison with related compounds. The structures of compounds 2 and 3 were confirmed by chemical interconversion. The isolated compounds exhibited IC50's of 0.03-1.67 mug/mL against murine tumor cells in an in vitro cytotoxicity assay

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