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Genomically intact endogenous feline leukemia viruses of recent origin

  1. Author:
    Roca, A. L.
    Peacon-Slattery, J.
    O'Brien, S. J.

  2. Author Address

    O'Brien, SJ, NCI, Lab Genom Divers, Ft Detrick, MD 21702 USA SAIC Frederick, Basic Res Program, Lab Genom Divers, Frederick, MD 21702 USA. NCI, Lab Genom Divers, Ft Detrick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Journal of Virology
    1. 78
    2. 8
    3. Pages: 4370-4375
  4. Type of Article: Article
  1. Abstract:

    We isolated and sequenced two complete endogenous feline leukemia viruses (enFeLVs), designated enFeLV-AGTT and enFeLV-GGAG. In enFeLV-AGTT, the open reading frames are reminiscent of a functioning FeLV genome, and the 5' and 3' long terminal repeat sequences are identical. Neither endogenous provirus is genetically fixed in cats but polymorphic, with 8.9 and 15.2% prevalence for enFeLV-AGTT and enFeLV-GGAG, respectively, among a survey of domestic cats. Neither provirus was found in the genomes of related species of the Felis genus, previously shown to harbor enFeLVs. The absence of mutational divergence, polymorphic incidence in cats, and absence in related species suggest that these enFeLVs may have entered the germ line more recently than previously believed, perhaps coincident with domestication, and reopens the question of whether some enFeLVs might be replication competent

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External Sources

  1. View record in Web of Science®
  2. WOS: 000220641600057

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