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Isolation and characterization of anti-HIV peptides from Dorstenia contrajerva and Treculia obovoidea

  1. Author:
    Bokesch, H. R.
    Charan, R. D.
    Meragelman, K. M.
    Beutler, J. A.
    Gardella, R.
    O'Keefe, B. R.
    McKee, T. C.
    McMahon, J. B.

  2. Author Address

    McKee, TC, NCI, SAIC Frederick Inc, Basic Res Program, Frederick, MD 21702 USA NCI, SAIC Frederick Inc, Basic Res Program, Frederick, MD 21702 USA. NCI, Ctr Canc Res, Mol Targets Dev Program, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Febs Letters
    1. 567
    2. 2-3
    3. Pages: 287-290
  4. Type of Article: Article
  1. Abstract:

    Using a high throughput screen based on the interaction of the HIV-1 gp41 ectodomain with the virucidal protein cyanovirin-N (CV-N), we isolated two new peptides which inhibited the binding of CV-N to gp41 and which subsequently showed anti-HIV activity in a whole cell assay. A 5-kDa (contrajervin) and 10 kDa (treculavirin) peptide were isolated from Dorstenia contrajerva and Treculia obovoidea, respectively. Treculavirin was composed of two subunits, each containing 50 amino acid residues, which are covalently linked by at least one disulfide bond between the subunits. Both peptides were shown to bind to gp41 and gp120 and to inhibit the cytopathic effects of HIV-1(RF) infection in a human T-lymphoblastoid cell line (CEM-SS). (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved

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  2. DOI: 10.1016/j.febslet.2004.04.085
  3. PMID: 15178338

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