Skip NavigationSkip to Content
Return Return to Search Results

Oxidative Dna Damage in Tissues of Pregnant Female Mice and Fetuses Caused By the Tobacco-Specific Nitrosamine, 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (Nnk)

  1. Author:
    Sipowicz, M. A.
    Amin, S.
    Desai, D.
    Kasprzak, K. S.
    Anderson, L. M.

  2. Author Address

    Sipowicz MA NCI FREDERICK CANC RES & DEV CTR DIV BASIC SCI COMPARAT CARCINOGENESIS LAB BLDG 538 RM 205 FREDERICK, MD 21702 USA AMER HLTH FDN VALHALLA, NY 10595 USA
    1. Year: 1997
  2. Journal: Cancer Letters
    1. 117
    2. 1
    3. Pages: 87-91
  4. Type of Article: Article
  1. Abstract:

    The tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), induces the promutagenic oxidative-damage DNA lesion, 8-oxo-2'-deoxyguanosine (8-oxo-dG), in adult animals. To investigate whether this alteration occurs in DNA after transplacental exposure, pregnant Swiss mice were administered single or multiple doses of NNK. The 8-oxo-dG was quantified in placenta, and maternal and fetal tissues. In maternal lungs, single and multiple doses of NNK significantly increased levels of 8-oxo-dG by 23% and 32%, respectively. In maternal liver, a significant 38% increase was observed after multiple dose treatment. In the fetuses, a significant 45% increase in 8-oxo-dG levels was observed in liver after multiple doses of NNK. This is the first demonstration of oxidative DNA damage after transplacental exposure to NNK, and supports the concept of maternal smoking as a contributor to the development of childhood cancer. (C) 1997 Elsevier Science Ireland Ltd. [References: 32]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel