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PAR-1 for the course of neurodegeneration

  1. Author:
    Fortini, M. E.
  2. Author Address

    Fortini, ME, NCI, Mol Genet Sect, Bldg 560,Romm 22-12, Frederick, MD 21702 USA NCI, Mol Genet Sect, Frederick, MD 21702 USA.
    1. Year: 2004
  1. Journal: Cell
    1. 116
    2. 5
    3. Pages: 631-632
  2. Type of Article: Article
  1. Abstract:

    The large number of kinases that phosphorylate the microtubule binding protein tau has posed a challenge to understanding their individual roles in turning this protein into a killer of neurons. A study in this issue of Cell (Nishimura et al., 2004) uses an elegant fusion of loss-of-function genetics and transgenic overexpression to make the case that the PAR-1 kinase stands at the head of a temporally ordered series of tau phosphorylations

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