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Signal transduction: IMPlications for Ras-dependent ERK signaling

  1. Author:
    Ory, S.
    Morrison, D. K.

  2. Author Address

    Ory, S, NCI, Lab Prot Dynam & Signaling, Frederick, MD 21702 USA NCI, Lab Prot Dynam & Signaling, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Current Biology
    1. 14
    2. 7
    3. Pages: R277-R278
  4. Type of Article: Article
  1. Abstract:

    Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mitogenic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase signaling by regulating the scaffolding activity of KSR

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