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Virus entry: Molecular mechanisms and biomedical applications

  1. Author:
    Dimitrov, D. S.

  2. Author Address

    Dimitrov, DS, NCI, Human Immunovirol & Computat Biol Grp, Lab Expt & Computat Biol, Ctr Canc Res, Bldg 469,Room 246,Miller Dr, Frederick, MD 21702 USA NCI, Human Immunovirol & Computat Biol Grp, Lab Expt & Computat Biol, Ctr Canc Res, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Nature Reviews Microbiology
    1. 2
    2. 2
    3. Pages: 109-122
  4. Type of Article: Review
  1. Abstract:

    Viruses have evolved to enter cells from all three domains of life - Bacteria, Archaea and Eukaryotes. Of more than 3,600 known viruses, hundreds can infect human cells and most of those are associated with disease. To gain access to the cell interior, animal viruses attach to host-cell receptors. Advances in our understanding of how viral entry proteins interact with their host-cell receptors and undergo conformational changes that lead to entry offer unprecedented opportunities for the development of novel therapeutics and vaccines

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