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DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development

  1. Author:
    Durkin, M. E.
    Avner, M. R.
    Huh, C. G.
    Yuan, B. Z.
    Thorgeirsson, S. S.
    Popescu, N. C.

  2. Author Address

    NCI, Expt Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA. NCI, SAIC Frederick, Pathol Histotechnol Lab, Vet Pathol Sect, Ft Detrick, MD 21702 USA Durkin, ME, NCI, Expt Carcinogenesis Lab, NIH, 37 Convent Dr, Bethesda, MD 20892 USA
    1. Year: 2005
    2. Date: FEB 14
  2. Journal: Febs Letters
    1. 579
    2. 5
    3. Pages: 1191-1196
  4. Type of Article: Article
  1. Abstract:

    DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1(-/-) embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved

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External Sources

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  2. DOI: 10.1016/j.febslet.2004.12.090
  3. View record in Web of Science®
  4. WOS: 000227210600037

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