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A common genetic variant in FCGR3A-V158F and risk of Kaposi sarcoma herpesvirus infection and classic Kaposi sarcoma

  1. Author:
    Brown, E. E.
    Fallin, M. D.
    Goedert, J. J.
    Chen, R.
    Whitby, D.
    Foster, C. B.
    Lauria, C.
    Alberg, A. J.
    Messina, A.
    Montella, M.
    Rezza, G.
    Vitale, F.
    Chanock, S. J.

  2. Author Address

    NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA. Johns Hopkins Univ, Sch Med, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD USA. NCI, Ctr Adv Technol, NIH, Dept Hlth & Human Serv, Gaithersburg, MD USA. NCI, Viral Epidemiol Sect, AIDS Vaccine Program, Sci Applicat Int Corp, Frederick, MD 21701 USA. Lega Italiana Lotta Contro Tumori, Sez Ragusa, Ragusa, Italy. Univ Catania, Dipartimento Sci Biomed, Catania, Italy. G Pascale Fdn, Natl Canc Inst, Dept Epidemiol, Naples, Italy. Ist Super Sanita, Epidemiol & Biostat Lab, I-00161 Rome, Italy. Univ Palermo, Dipartimento Igiene & Microbiol Giuseppe DAlessan, Palermo, Italy Brown, EE, NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, 6120 Execut Blvd,EPS 8003,MSC 7248, Rockville, MD 20852 USA
    1. Year: 2005
    2. Date: MAR
  2. Journal: Cancer Epidemiology Biomarkers & Prevention
    1. 14
    2. 3
    3. Pages: 633-637
  4. Type of Article: Article
  1. Abstract:

    Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis of Kaposi sarcoma herpesvirus (KSHV) infection and risk of acquired immunodeficiency syndrome-associated Kaposi sarcoma. Using DNA from two HIV seronegative case-control populations in Italy, we examined whether the functional FCGR3A-VI58F variant was associated with risk of KSHV infection or classic Kaposi sarcoma (CKS). In population I, we examined FCGR3A variants and risk of KSHV infection in 34 KSHV latent nuclear antigen (LANA)-seropositive and 120 LANA-seronegative adults from Sardinia (52% male; median age, 45 years; range, 31-60), whereas in population II, we examined risk of CKS from 133 CKS cases and 172 KSHV LANA-seropositive controls from Sicily, Rome, and Naples (70% males; median age, 74 years; range, 29-91). FCGR3A variants were determined by direct sequence analysis of a nested PCR of genomic DNA assay using allele-specific primers. KSHV LANA was determined by immunofluorescence assay. Overall, compared with the 158F allele, 158V was overrepresented among controls from both Mediterranean populations (frequency = 0.52 and 0.51, respectively). After controlling for age, 158V homozygous women were at increased risk of KSHV infection and CKS compared with 158F homozygous women [odds ratio (OR), 8.7; 95% confidence interval (95% CI), 0.8-98 and OR, 3.8; 95% Cl, 1.0-14, respectively], whereas homozygous men were at decreased risk (OR, 0.4; 95% Cl, 0.1-2.3 and OR, 0.4; 95% CI, 0.2-0.8, respectively). Significant gene-dose effects were observed among men and women at risk for CKS (P-trend <= 0.05). Our findings suggest that gender differences could possibly modify the effect of FCGR3A on risk of KSHV infection and CKS. Additional studies are required to confirm these relationships and determine their etiologic significance

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  2. WOS: 000227545900017

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