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IL-3 induces inhibitor of DNA-binding protein-1 in hemopoietic progenitor cells and promotes myeloid cell development

  1. Author:
    Leeanansaksiri, W.
    Wang, H.
    Gooya, J. M.
    Renn, K.
    Abshari, M.
    Tsai, S.
    Keller, J. R.

  2. Author Address

    NCI, Basic Res Program, SAIC Frederick, Frederick, MD 20702 USA. NCI, Lab Mol Immunoregulat, Frederick, MD 20702 USA. NCI, Canc Res Ctr, Frederick, MD 20702 USA. Univ Utah, Sch Med, Div Hematol, Salt Lake City, UT 84132 USA Keller, JR, NCI, Basic Res Program, SAIC Frederick, Bldg 560,Room 12-03, Frederick, MD 20702 USA
    1. Year: 2005
    2. Date: JUN 1
  2. Journal: Journal of Immunology
    1. 174
    2. 11
    3. Pages: 7014-7021
  4. Type of Article: Article
  1. Abstract:

    Hemopoiesis depends on the expression and regulation of transcription factors, which control the maturation of specific cell lineages. We found that the helix-loop-helix transcription factor inhibitor of DNA-binding protein 1 (Id1) is not expressed in hemopoietic stem cells (HSC), but is increased in more committed myeloid progenitors. 141 levels decrease during neutrophil differentiation, but remain high in differentiated macrophages. Id1 is expressed at low levels or is absent in developing lymphoid or erythroid cells. Id1 expression can be induced by IL-3 in HSC during myeloid differentiation, but not by growth factors that promote erythroid and B cell development. HSC were transduced with retroviral vectors that express Id1 and were transplanted in vivo to evaluate their developmental potential. Overexpression of Id1 in HSC promotes myeloid but impairs B and erythroid cell development. Enforced expression of 141 in committed myeloid progenitor cells inhibits granulocyte but not macrophage differentiation. Therefore, Id1 may be part of the mechanism regulating myeloid vs lymphoid/erythroid cell fates, and macrophage vs neutrophil maturation

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External Sources

  1. View record in Web of Science®
  2. WOS: 000229298400058

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