Skip NavigationSkip to Content
Return Return to Search Results

Pathological crystallography: case studies of several unusual macromolecular crystals

  1. Author:
    Dauter, Z.
    Botos, I.
    Laronde-Leblanc, N.
    Wlodawer, A.

  2. Author Address

    NCI, Prot Struct Sect, Macromol Crystallog Lab, Frederick, MD 21702 USA. NCI, Synchrotron Radiat Res Sect, Macromol Crystallog Lab, Argonne, IL 60439 USA. Argonne Natl Lab, Biosci Div, Argonne, IL 60439 USA Wlodawer, A, NCI, Prot Struct Sect, Macromol Crystallog Lab, Frederick, MD 21702 USA
    1. Year: 2005
    2. Date: JUL
  2. Journal: Acta Crystallographica Section D-Biological Crystallography
    1. 61
    2. Part 7
    3. Pages: 967-975
  4. Type of Article: Article
  1. Abstract:

    Although macromolecular crystallography is rapidly becoming largely routine owing to advances in methods of data collection, structure solution and refinement, difficult cases are still common. To remind structural biologists about the kinds of crystallographic difficulties that might be encountered, case studies of several successfully completed structure determinations that utilized less than perfect crystals are discussed here. The structure of the proteolytic domain of Archaeoglobus fulgidus Lon was solved with crystals that contained superimposed orthorhombic and monoclinic lattices, a case not previously described for proteins. Another hexagonal crystal form of this protein exhibited an unusually high degree of non-isomorphism. Crystals of A. fulgidus Rio1 kinase exhibited both pseudosymmetry and twinning. Ways of identifying the observed phenomena and approaches to solving and refining macromolecular structures when only less than perfect crystals are available are discussed here

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000230113000016

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel