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Human leukocyte antigen class I and II haplotypes and risk of cervical cancer

  1. Author:
    Carreon, J. D.
    Martin, M. P.
    Hildesheim, A.
    Gao, X.
    Schiffman, M.
    Herrero, R.
    Bratti, M. C.
    Sherman, M. E.
    Zaino, R. J.
    Carrington, M.
    Wang, S. S.

  2. Author Address

    NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. NCI, Basic Res Program, Lab Genom Divers, SAIC Frederick Inc, Frederick, MD 21702 USA. Proyecto Epidemiol Guanacaste, Guanacaste, Costa Rica. Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA Carreon, JD, NCI, DCEG, 6120 Execut Blvd, Rockville, MD 20852 USA
    1. Year: 2005
    2. Date: OCT
  2. Journal: Tissue Antigens
    1. 66
    2. 4
    3. Pages: 321-324
  4. Type of Article: Article
  1. Abstract:

    Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n = 365) and cytologically normal population controls (n = 681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in > 5% of US Caucasians but in < 1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in < 1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes

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External Sources

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  2. DOI: 10.1111/j.1399-0039.2005.00478.x
  3. View record in Web of Science®
  4. WOS: 000232050800010

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