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Correlates of human herpesvirus-8 DNA detection among adults in Italy without Kaposi sarcoma

  1. Author:
    Brown, E. E.
    Whitby, D.
    Vitale, F.
    Fei, P. C.
    Del Carpio, C.
    Marshall, V.
    Alberg, A. J.
    Serraino, D.
    Messina, A.
    Gafa, L.
    Goedert, J. J.

  2. Author Address

    NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, DHHS,NIH, Rockville, MD 20852 USA. Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA. NCI Frederick, SAIC Frederick, AIDS Vaccine Program, Viral Epidemiol Sect, Frederick, MD USA. Univ Palermo, Dipartimento Igiene & Microbiol Giusepe DAlessand, Palermo, Italy. San Gallicano Hosp, Rome, Italy. Osped Bambini Brescia, ARNAS Serv Anal Chim Clin, Palermo, Italy. IRCCS, Ist Nazl Malattie Infett L Spallanzani, Dept Epidemiol, Rome, Italy. Catania Univ, Dept Biomed Sci, Catania, Italy. Lega Italiana Lotta Contro & Tumori, Ragusa, Italy. Fdn G Pascale, Ist Tumori Napoli, Unita Operat Epidemiol, Naples, Italy. Ist Super Sanita, Epidemiol & Biostat Lab, I-00161 Rome, Italy. Ist Dermatopat Immacolata, Rome, Italy. Res Triangle Inst, Rockville, MD USA. NCI, Viral Epidemiol Branch, Rockville, MD USA Brown, EE, NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, DHHS,NIH, 6120 Execut Blvd,EPS 8005 MSC 7248, Rockville, MD 20852 USA
    1. Year: 2005
    2. Date: OCT
  2. Journal: International Journal of Epidemiology
    1. 34
    2. 5
    3. Pages: 1110-1117
  4. Type of Article: Article
  1. Abstract:

    Background The presence of Human Herpesvirus-8 (HHV8) DNA is predictive of Kaposi sarcoma (KS) among patients with HIV-associated or iatrogenic immunosuppression. However, correlates of HHV8-DNA detection in the general population remain undefined.Methods We assessed correlates of HHV8-DNA detection among Italian adults without KS who had antibodies against HHV8-latent nuclear antigen by immunofluorescence assay. HHV8-K6 DNA sequences were detected in peripheral blood mononuclear cells using TaqMan PCR.Results Of the 158 subjects 26 (16.5%) had detectable HHV8-DNA [median copies/million cells, 53; (13-2128)]. Adjusted for age, sex, and laboratory, HHV8-DNA was detected more frequently in participants with > 7 total residents in the childhood home [OR = 3.7 (1.5-9.1)], > 2 younger siblings [OR = 2.6 (1.1-6.5)], and current cardiovascular [OR = 3.6 (1.3-9.7)] or renal [OR = 3.1 (1.2-8.0)] disease. Excluding the participants using immune modulating drugs, HHV8-DNA was more frequent among those with low red blood cells (RBC) [< 4.5 10(6)/mu l; OR = 5.3 (1.7-16.2)], slightly elevated mean corpuscular volume [> 92 mu m(3)/red cell; OR = 2.8 (1.0-7.8)], and mild thrombocytopenia [< 151 K/mu l; OR = 5.6 (1.9-16.3)].Conclusions Presence of HHV8-DNA in elderly Italians is associated with childhood crowding, low RBCs, and platelets, perhaps indicating roles for early infection and chronic inflammation. These risk factors are the first to be reported for non-immunosuppressed HHV8-seropositive adults

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  2. WOS: 000232594600028

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