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The adaptive immune response in neonatal cerebral white matter damage

  1. Author:
    Leviton, A.
    Dammann, O.
    Durum, S. K.

  2. Author Address

    Childrens Hosp, Neuroepidemiol Unit, Boston, MA 02215 USA. Hannover Med Sch, Dept Obstet, Perinatal Infect Dis Epidemiol Unit, D-3000 Hannover, Germany. Hannover Med Sch, Dept Pediat, Perinatal Infect Dis Epidemiol Unit, D-3000 Hannover, Germany. NCI, Immunol Cytokine Grp, Frederick, MD 21701 USA Leviton, A, Childrens Hosp, Neuroepidemiol Unit, 1 Autumn St,720, Boston, MA 02215 USA
    1. Year: 2005
    2. Date: DEC
  2. Journal: Annals of Neurology
    1. 58
    2. 6
    3. Pages: 821-828
  4. Type of Article: Article
  1. Abstract:

    Hypotheses that inflammation contributes to neonatal cerebral white matter damage have evolved over the last three decades. The latest, expanded here, suggests that the adaptive immune system contributes to the intensity and duration of the processes that result in damage to cerebral white matter in the fetus and newborn. We propose several mechanisms by which fetal T lymphocytes could be activated during fetal exposure to infection. These include specific recognition of bacterial antigens, specific recognition of autoantigens, polyclonal activation by Toll-like receptors, and bystander activation by cytokines

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External Sources

  1. View record in Web of Science®
  2. WOS: 000233703900002

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