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Interferon Expression By B Cells

  1. Author:
    Young, H. A.

  2. Author Address

    Young HA NCI FREDERICK CANC RES & DEV CTR HEAD CELLULAR & MOL IMMUNOL SECT LAB EXPT IMMUNOL DIV BASIC SCI FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Methods (Duluth)
    1. 11
    2. 1
    3. Pages: 112-115
  4. Type of Article: Article
  1. Abstract:

    Interferons have effects on many facets of immune system development, maturation, and function. B cells are a target for the interferons, causing alterations in cell differentiation and gene expression. However, production of interferons by B cells has not been widely studied. In this review I will discuss the limited literature on B-cell interferon production. In addition I will describe results obtained from a transgenic model in which interferon-gamma production has been targeted to the B-cell compartment. In this animal, B-cell development is blocked, reflecting the deleterious effects that aberrant expression of interferon can have on this cell population. (C) 1997 Academic Press, Inc. [References: 24]

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