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Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantation

  1. Author:
    Welniak, L. A.
    Kuprash, D. V.
    Tumanov, A. V.
    Panoskaltsis-Mortari, A.
    Blazar, B. R.
    Sun, K.
    Nedospasov, S. A.
    Murphy, W. J.

  2. Author Address

    Univ Nevada, Sch Med, Dept Immunol & Microbiol, Reno, NV 89557 USA. Russian Acad Sci, Inst Mol Biol, Lab Mol Immunol, Moscow, Russia. Univ Minnesota, Ctr Canc, Div BMT, Minneapolis, MN 55455 USA. Univ Minnesota, Dept Pediat, Div BMT, Minneapolis, MN 55455 USA. SAIC Frederick, Basic Res Program, Frederick, MD USA. Natl Canc Inst, Canc Res Ctr, Mol Immunoregulat Lab, Frederick, MD USA Welniak, LA, Univ Nevada, Sch Med, Dept Immunol & Microbiol, Mail Stop 199, Reno, NV 89557 USA
    1. Year: 2006
    2. Date: JAN 1
  2. Journal: Blood
    1. 107
    2. 1
    3. Pages: 410-412
  4. Type of Article: Article
  1. Abstract:

    Graft-versus-host disease (GVHD) is a multistep disease process following allogeneic bone marrow transplantation (BMT). It has been postulated that the induction of acute GVHD requires the presence of Peyer patches (PPs). A new tumor necrosis factor (TNF)-deficient strain has been developed that totally lacks PPs and displays the defects characteristic of TNF ablation but not lymphotoxin-associated defects characterized by lack of both PPs and lymph nodes. To determine the necessity of PPs in acute lethal GVHD induction, we transplanted full major histocompatibility complex (MHC)-mismatched grafts into myeloablated TNF knockout recipients. No differences in the survival or GVHD-associated histopathologic lesions were observed between the recipients. We conclude that neither PPs nor host TNIF-alpha is required for the development of acute lethal GVHD in mice that undergo myeloablative conditioning and allogeneic BMT

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  2. WOS: 000234235200066

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