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Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes

  1. Author:
    Frahm, N.
    Kiepiela, P.
    Adams, S.
    Linde, C. H.
    Hewitt, H. S.
    Sango, K.
    Feeney, M. E.
    Addo, M. M.
    Lichterfeld, M.
    Lahaie, M. P.
    Pae, E.
    Wurcel, A. G.
    Roach, T.
    St John, M. A.
    Altfeld, M.
    Marincola, F. M.
    Moore, C.
    Mallal, S.
    Carrington, M.
    Heckerman, D.
    Allen, T. M.
    Mullins, J. I.
    Korber, B. T.
    Goulder, P. J. R.
    Walker, B. D.
    Br, er

  2. Author Address

    Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02115 USA. Harvard Univ, Sch Med, Div AIDS, Boston, MA 02115 USA. Univ KwaZulu Natal, ZA-4015 Durban, South Africa. Clin Ctr Natl Inst Hlth, Bethesda, MD 20892 USA. Fenway Community Hlth Ctr, Boston, MA 02115 USA. Lemuel Shattuck Hosp, Boston, MA 02115 USA. Queen Elizabeth Hosp, Bridgetown, Barbados. Royal Perth Hosp, Ctr Clin Immunol & Biomed Stat, Murdoch, WA 6000, Australia. Murdoch Univ, Murdoch, WA 6150, Australia. NCI, Frederick Canc Res & Dev Ctr, Lab Genom Divers, Basic Res Program, Frederick, MD 21702 USA. Microsoft Corp, Redmond, WA 98052 USA. Univ Washington, Seattle, WA 98195 USA. Santa Fe Inst, Santa Fe, NM 87501 USA. Los Alamos Natl Lab, Los Alamos, NM 87545 USA. Univ Oxford, Oxford OX1 3SY, England. Howart Hughes Med Inst, Chevy Chase, MD 20185 USA Brander, C, Harvard Univ, Sch Med, Massachusetts Gen Hosp, Partners AIDS Res Ctr, Boston, MA 02115 USA
    1. Year: 2006
    2. Date: FEB
  2. Journal: Nature Immunology
    1. 7
    2. 2
    3. Pages: 173-178
  4. Type of Article: Article
  1. Abstract:

    Despite limited data supporting the superiority of dominant over subdominant responses, immunodominant epitopes represent the preferred vaccine candidates. To address the function of subdominant responses in human immunodeficiency virus infection, we analyzed cytotoxic T lymphocyte responses restricted by HLA-B*1503, a rare allele in a cohort infected with clade B, although common in one infected with clade C. HLA-B*1503 was associated with reduced viral loads in the clade B cohort but not the clade C cohort, although both shared the immunodominant response. Clade B viral control was associated with responses to several subdominant cytotoxic T lymphocyte epitopes, whereas their clade C variants were less well recognized. These data suggest that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination of subdominant yet effective epitopes from circulating viral populations

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External Sources

  1. View record in Web of Science®
  2. WOS: 000234801700018

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