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Distribution and three-dimensional structure of AIDS virus envelope spikes

  1. Author:
    Zhu, P.
    Liu, J.
    Bess, J.
    Chertova, E.
    Lifson, J. D.
    Grise, H.
    Ofek, G. A.
    Taylor, K. A.
    Roux, K. H.

  2. Author Address

    Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA. Florida State Univ, Inst Mol Biophys, Tallahassee, FL 32306 USA. NCI, AIDS Vaccine Program, SAIC Frederick Inc, Frederick, MD 21702 USA. NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA Roux, KH, Florida State Univ, Dept Biol Sci, B-157, Tallahassee, FL 32306 USA
    1. Year: 2006
    2. Date: JUN 15
  2. Journal: Nature
    1. 441
    2. 7095
    3. Pages: 847-852
  4. Type of Article: Article
  1. Abstract:

    Envelope glycoprotein (Env) spikes on AIDS retroviruses initiate infection of host cells and are therefore targets for vaccine development. Though crystal structures for partial Env subunits are known, the structure and distribution of native Env spikes on virions is obscure. We applied cryoelectron microscopy tomography to define ultrastructural details of spikes. Virions of wild-type human immunodeficiency virus 1 (HIV-1) and a mutant simian immunodeficiency virus (SIV) had similar to 14 and similar to 73 spikes per particle, respectively, with some clustering of HIV-1 spikes. Three-dimensional averaging showed that the surface glycoprotein (gp120) 'head' of each subunit of the trimeric SIV spike contains a primary mass, with two secondary lobes. The transmembrane glycoprotein 'stalk' of each trimer is composed of three independent legs that project obliquely from the trimer head, tripod-like. Reconciling available atomic structures with the three-dimensional whole spike density map yields insights into the orientation of Env spike structural elements and possible structural bases of their functions

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External Sources

  1. View record in Web of Science®
  2. WOS: 000238254100036

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