Skip NavigationSkip to Content
Return Return to Search Results

Antiviral oligo- and polyribonucleotides containing selected triazolo

  1. Author:
    Tutonda, M. G.
    Buckheit, R. W.
    Agrawal, V. K.
    Broom, A. D.

  2. Author Address

    Broom AD Univ Utah, Dept Med Chem 20 South 2030 East,295 Biomed Polymers Res Bldg Salt Lake City, UT 84112 USA Univ Utah, Dept Med Chem Salt Lake City, UT 84112 USA Aral Biosynthet Inc Salt Lake City, UT 84115 USA Frederick Canc Res & Dev Ctr, So Res Inst Frederick, MD 21701 USA
    1. Year: 1998
  2. Journal: Journal of Medicinal Chemistry
    1. 41
    2. 25
    3. Pages: 4958-4964
  4. Type of Article: Article
  1. Abstract:

    Several amphipathic (hydrophobic base, hydrophilic backbone) polyribonucleotides have recently been shown to have potent antiviral activity against HIV and human cytomegalovirus (HCMV). The working hypothesis developed during these studies was that the ability to form an ordered, non-hydrogen-bonded array in solution was an important criterion for activity. To explore further the role of structure and molecular size on the inhibition of virus replication, one new polynucleotide and two 32-mer oligonucleotides based on the triazolo[2,3-a]purine ring system have now been prepared. High-molecular-weight polynucleotide 4a (PTPR) and sulfur-containing 32-mer 5b (TTPR) were moderately active against HIV but showed greater potency against HDMV than ganciclovir. Both 4a and 5b gave clear evidence of cooperative melting behavior, whereas inactive 32-mer 5a showed no such behavior. [References: 21]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel