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A model of drug delivery to normal and cancer cells by anti body-targeted nanoliposomes

  1. Author:
    Sidorov, I. A.
    Blumenthal, R.
    Dimitrov, D. S.

  2. Author Address

    NCI, CCR, Ctr Canc Res Nanobiol Program, Prot Interact Grp,NIH, Frederick, MD 21702 USA. NCI, CCR, Ctr Canc Res Nanobiol Program, Membrane Struct& Funct Sect,NIH, Frederick, MD 21702 USA.;Sidorov, IA, NCI, CCR, Ctr Canc Res Nanobiol Program, Prot Interact Grp,NIH, Frederick, MD 21702 USA.
    1. Year: 2006
    2. Date: Jun
  2. Journal: Journal of Computational and Theoretical Nanoscience
    1. 3
    2. 3
    3. Pages: 405-411
  4. Type of Article: Article
  5. ISSN: 1546-1955
  1. Abstract:

    A mathematical model of drug delivery to cells by antibody-conjugated liposomes is presented. The model includes variables describing concentration of free and liposome-encapsulated drug in medium, intracellular drug amount and concentration of target cells. It accounts for mechanisms of active and passive transport through cell membrane and Hill-type dependence of rate of cell death on intracellular drug amount. The model has been applied to data for cytotoxic effect of free or liposome-encapsulated doxorubicin on target melanoma cells in culture. Fitting of experimental data showed increased efficacy of 24 hours exposure with both free and liposome encapsulated doxorubicin. Simulation with parameter values after data fitting demonstrated the existence of temporary increase in intracellular amount of toxin per cell with liposome delivery, more efficient cell killing of tumor cells by liposome-encapsulated drug in culture consisting of mixture of tumor and normal cells, and non-linear dependence of therapeutic effect on drug concentration for normal and tumor cell mixture. The results may help in the design of therapeutic and diagnostic approaches.

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External Sources

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  2. DOI: 10.1166/jctn.2006.011
  3. View record in Web of Science®
  4. WOS: 000238923900009

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