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Determination of paclitaxel in human plasma following the administration of Genaxol or Genetaxyl by liquid chromatography/tandem mass spectrometry

  1. Author:
    Gardner, E. R.
    Liau, C. T.
    Chu, Z. T. E.
    Figg, W. D.
    Sparreboom, A.

  2. Author Address

    NCI, Clin Pharmacol Res Core, Canc Res Ctr, Bethesda, MD 20892 USA. SAIC Frederick Inc, Clin Pharmacol Res Core, NCI Frederick, Frederick, MD 21702 USA. Chang Gung Mem Hosp, Taipei, Taiwan. Genovate Biotechnol, Taipei, Taiwan.;Figg, WD, NCI, Clin Pharmacol Res Core, Canc Res Ctr, 9000 Rockville Pike,Bldg 10,Room 5A01, Bethesda, MD 20892 USA.;wdfigg@helix.nih.gov
    1. Year: 2006
  2. Journal: Rapid Communications in Mass Spectrometry
    1. 20
    2. 14
    3. Pages: 2170-2174
  4. Type of Article: Article
  5. ISSN: 0951-4198
  1. Abstract:

    A sensitive and specific assay for paclitaxel in plasma has been developed to overcome limitations in previously published assays, using liquid chromatography with tandem mass spectrometric detection. Plasma samples (100 mu L) were subjected to liquid-liquid extraction with 1-chlorobutane/acetonitrile (4:1, v/v), with [H-2(5)]paclitaxel employed as the internal standard. Chromatography was carried out with a Waters SymmetryShield C8 column (50 X 2.1 mm, 3.5 mu m). The total run time, including equilibration, was 8 min, using a gradient of acetonitrile and 10 mM ammonium formate, pH 4.0. The assay is accurate and precise over the range of 2-2500 ng/mL and has been successfully applied to study the clinical pharmacokinetics of two formulations of paclitaxel, Genaxol and Genetaxyl, given orally and intravenously. Copyright (c) 2006 John Wiley & Sons, Ltd.

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  2. DOI: 10.1002/rcm.2577
  3. View record in Web of Science®
  4. WOS: 000239054700015

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