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Alternate polypurine tracts affect Rous sarcoma virus integration in vivo

  1. Author:
    Oh, J.
    Chang, K. W.
    Alvord, W. G.
    Hughes, S. H.

  2. Author Address

    NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA. NCI, Data Management Serv, Frederick, MD 21702 USA.;Hughes, SH, NCI, HIV Drug Resistance Program, POB B,Bldg 539,Rm 130A, Frederick, MD 21702 USA.;Hughes@ncifcrf.gov
    1. Year: 2006
    2. Date: Oct
  2. Journal: Journal of Virology
    1. 80
    2. 20
    3. Pages: 10281-10284
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    When the endogenous polypurine tract (PPT) of the Rous sarcoma virus (RSV)-derived vector RSVP(A)Z was replaced with alternate retroviral PPTs, the fraction of unintegrated viral DNA with the normal consensus ends significantly decreased and the retention of part of the PPT significantly increased. If the terminus of the U3 long terminal repeat (LTR) is aberrant, RSV integrase can correctly process and integrate the normal U5 LTR into the host genome. However, the canonical CA is not involved in joining the aberrant U3 LTR to the host DNA, generating either large duplications or deletions of the host sequences instead of the normal 5- or 6-bp duplication.

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External Sources

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  2. DOI: 10.1128/jvi.00361-06
  3. View record in Web of Science®
  4. WOS: 000241046800039

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