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Crinamine from Crinum asiaticum var.japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2

  1. Author:
    Kim, Y. H.
    Park, E. J.
    Park, M. H.
    Badarch, U.
    Woldemichael, G. M.
    Beutler, J. A.

  2. Author Address

    Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea. NCI, Mol Targets Dev Program, Frederick, MD 21702 USA. NCI, SAIC Frederick Inc, Frederick, MD 21702 USA.;Kim, YH, Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea.;yhk@cnu.ac.kr
    1. Year: 2006
    2. Date: Oct
  2. Journal: Biological & Pharmaceutical Bulletin
    1. 29
    2. 10
    3. Pages: 2140-2142
  4. Type of Article: Article
  5. ISSN: 0918-6158
  1. Abstract:

    In a search for natural product inhibitors of hypoxia inducible factor-1 (HIF-1) function, crinamine (1), a crinane type alkaloid, showed potent dose dependent inhibition (IC50 = 2.7 mu m) of HIF-1 alpha in a cell-based reporter gene assay. Crinamine (1) was isolated from the aerial parts of Crinum asiaticum var.japonicum together with ly-corine (2), norgalanthamine (3) and epinorgalanthamine (4). The other components (2-4) showed no significant inhibition of HIF-1 alpha induced transcriptional activity.

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  1. View record in Web of Science®
  2. WOS: 000241546600030

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