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A practical synthesis of fully protected L-gamma-carboxyglutamic acid

  1. Author:
    Jiang, S.
    Lai, C. C.
    Kelley, J. A.
    Roller, P. P.

  2. Author Address

    NCI, CCR, Med Chem Lab, NIH, Frederick, MD 21702 USA.;Roller, PP, NCI, CCR, Med Chem Lab, NIH, Frederick, MD 21702 USA.;proll@helix.nih.gov
    1. Year: 2006
    2. Date: Jan
  2. Journal: Tetrahedron Letters
    1. 47
    2. 1
    3. Pages: 23-25
  4. Type of Article: Article
  5. ISSN: 0040-4039
  1. Abstract:

    We have developed a new synthetic route for the preparation of Fmoc protected L-gamma-carboxyglutamic acid in 60% overall yield (> 99% ee) via a six-step synthesis from D-Garner's aldehyde. An aldol condensation and the selective cleavage of the acetonide protective group are key steps. Published by Elsevier Ltd.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.tetlet.2005.10.121
  3. View record in Web of Science®
  4. WOS: 000234092900004

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