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Interleukin-7 receptor expression: intelligent design

  1. Author:
    Mazzucchelli, R.
    Durum, S. K.

  2. Author Address

    NCI, Lab Mol Immunoregulat, Canc & Inflammat Program, Ctr Canc Res,NIH, Frederick, MD 21702 USA.;Durum, SK, NCI, Lab Mol Immunoregulat, Canc & Inflammat Program, Ctr Canc Res,NIH, Bldg 56,Room 31-71, Frederick, MD 21702 USA.;durums@mail.nih.gov
    1. Year: 2007
    2. Date: Feb
  2. Journal: Nature Reviews Immunology
    1. 7
    2. 2
    3. Pages: 144-154
  4. Type of Article: Review
  5. ISSN: 1474-1733
  1. Abstract:

    Interleukin-7 (IL-7) is produced by stromal cells in lymphoid tissues and is required for the development of T cells and for their persistence in the periphery. Unlike many other cytokines that act on lymphocytes, IL-7 production by stromal cells is not substantially affected by extrinsic stimuli. So, the amount of available IL-7 protein is thought to be regulated by the rate that it is scavenged by T cells. As we review here, there is mounting evidence indicating that the amount of IL-7 receptor expressed on a cell not only determines how vigorously the cell responds to IL-7, but it can also determine how efficiently the cell consumes IL-7 and, therefore, affect the supply of this limiting resource in the niche.

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External Sources

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  2. DOI: 10.1038/nri2023
  3. View record in Web of Science®
  4. WOS: 000243839200013

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