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A high-resolution structure of ligand-free human glutamate carboxypeptidase II

  1. Author:
    Barinka, C.
    Starkova, J.
    Konvalinka, J.
    Lubkowski, J.

  2. Author Address

    Ctr Canc Res, Natl Canc Inst Frederick, Frederick, MD 21702 USA. Acad Sci Czech Republ, Gilead Sci Inc, CZ-6610 Prague 6, Czech Republic. Acad Sci Czech Republ, IOCB Res Ctr, CZ-6610 Prague 6, Czech Republic. Charles Univ Prague, Dept Biochem, Fac Nat Sci, CZ-2030 Prague, Czech Republic.;Barinka, C, Ctr Canc Res, Natl Canc Inst Frederick, Frederick, MD 21702 USA.;cyril@ncifcrf.gov
    1. Year: 2007
    2. Date: Mar
  2. Journal: Acta Crystallographica Section F-Structural Biology and Crystallization Communications
    1. 63
    2. Pages: 150-153
  4. Type of Article: Article
  5. ISSN: 1744-3091
  1. Abstract:

    Human glutamate carboxypeptidase II ( GCPII; EC 3.4.17.21) is an established marker for prostate-cancer diagnosis as well as a candidate therapeutic target for the treatment of diverse pathologies that involve glutamatergic transmission. Structural data on GCPII are thus valuable for the design and optimization of GCPII-specific inhibitors and diagnostic probes. The currently available structure of ligand-free GCPII was refined to a resolution of 3.5 angstrom. This work reports the structure of the protein refined to 1.65 angstrom resolution, with crystallographic values of R = 0.207 and R-free = 0.228. The new structure extends the resolution appreciably and the new model based on this data shows significant differences when compared with the previously published model.

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External Sources

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  2. DOI: 10.1107/s174430910700379x
  3. View record in Web of Science®
  4. WOS: 000244520800001

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