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Principles of nanostructure design with protein building blocks

  1. Author:
    Tsai, C. J.
    Zheng, J.
    Zanuy, D.
    Haspel, N.
    Wolfson, H.
    Aleman, C.
    Nussinov, R.

  2. Author Address

    SAIC Frederick Inc, Ctr Canc Res NAnobiol Program, NCI Frederick, Basic Res Program, Frederick, MD 21702 USA. Univ Politecn Catalunya, Dept Engn Quim, ETS Engn Ind, E-08028 Barcelona, Spain. Tel Aviv Univ, Sch Comp Sci, IL-69978 Tel Aviv, Israel. Tel Aviv Univ, Sackler Inst Mol Med, Dept Human Genet & Mol Med, Sackler Sch Med, IL-69978 Tel Aviv, Israel.;Nussinov, R, SAIC Frederick Inc, Ctr Canc Res NAnobiol Program, NCI Frederick, Basic Res Program, Frederick, MD 21702 USA.;ruthn@ncifcrf.gov
    1. Year: 2007
    2. Date: Jul
  2. Journal: Proteins-Structure Function and Bioinformatics
    1. 68
    2. 1
    3. Pages: 1-12
  4. Type of Article: Review
  5. ISSN: 0887-3585
  1. Abstract:

    Currently there is increasing interest in nanostructures and their design. Nanostructure design involves the ability to predictably manipulate the properties of the self-assembly of autonomous units. Autonomous units have preferred conformational states. The units can be synthetic material science-based or derived from functional biological macromolecules. Autonomous biological building blocks with available structures provide an extremely rich and useful resource for design. For proteins, the structural databases contain large libraries of protein molecules and their building blocks with a range of shapes, surfaces, and chemical properties. The introduction of engineered synthetic residues or short peptides into these can expand the available chemical space and enhance the desired properties. Here we focus on the principles of nanostructure design with protein building blocks.

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External Sources

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  2. DOI: 10.1002/prot.21413
  3. View record in Web of Science®
  4. WOS: 000246894800001

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