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Post-transcriptional control of the interferon system

  1. Author:
    Khabar, K. S. A.
    Young, H. A.

  2. Author Address

    King Faisal Specialist Hosp & Res Ctr, Program BioMol Res, Riyadh 11211, Saudi Arabia. Natl Canc Inst, Canc Res Ctr, Expt Immunol Lab, Ft Detrick, MD 21702 USA.;Khabar, KSA, King Faisal Specialist Hosp & Res Ctr, Program BioMol Res, P3354,MBC-03,Takhasusi Rd, Riyadh 11211, Saudi Arabia.;khabar@kfshrc.edu.sa
    1. Year: 2007
    2. Date: Jun-Jul
  2. Journal: Biochimie
    1. 89
    2. 6-7
    3. Pages: 761-769
  4. Type of Article: Article
  5. ISSN: 0300-9084
  1. Abstract:

    The interferon (IFN) system is a well-controlled network of signaling, transcriptional, and post-transcriptional processes that orchestrate host defense against microbes. The IFN response comprises a multi-array of IFN-stimulated gene products that mediate a variety of biological processes designed to control infection and regulate specific immune responses. In this review, we focus on post-transcriptional mechanisms of gene regulation that occur during the course of IFN induction and during the response of cells to IFN. Post-transcriptional mechanisms involve different levels of regulation such as mRNA stability, alternative splicing, and translation. Such controls offer a fine tuning mechanism for efficient and rapid response and as a negative feedback control in IFN biosynthesis and response. (C) 2007 Elsevier Masson SAS. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.biochi.2007.02.008
  3. View record in Web of Science®
  4. WOS: 000248502100009

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