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Computational design of an RNA hexagonal nanoring and an RNA nanotube

  1. Author:
    Yingling, Y. G.
    Shapiro, B. A.

  2. Author Address

    NCI, NIH, Ctr Canc Res Nanobiol Program, Frederick, MD 21702 USA.;Shapiro, BA, NCI, NIH, Ctr Canc Res Nanobiol Program, Frederick, MD 21702 USA.;bshapiro@ncifcrf.gov
    1. Year: 2007
    2. Date: Aug
  2. Journal: Nano Letters
    1. 7
    2. 8
    3. Pages: 2328-2334
  4. Type of Article: Article
  5. ISSN: 1530-6984
  1. Abstract:

    The combination of computer modeling, RNA structure versatility, and siRNA function can be efficiently used to design an all-RNA nanoparticle capable of siRNA delivery. Here, we present a computational design of an RNA nanoring and a nanotube. An RNA nanoring consists of six simple linear building blocks that are assembled together via known noncovalent loop-loop contacts based on RNAI/RNAII inverse sequences. The helical sequences of the building blocks can include siRNAs for drug delivery.

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External Sources

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  2. DOI: 10.1021/nl070984r
  3. View record in Web of Science®
  4. WOS: 000248657800030

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