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Lsh controls Hox gene silencing during development

  1. Author:
    Xi, S. C.
    Zhu, H. M.
    Xu, H.
    Schmidtmann, A.
    Geiman, T. M.
    Muegge, K.

  2. Author Address

    NCI, Lab Canc Prevent, SAIC Frederick, Frederick, MD 21702 USA.;Muegge, K, NCI, Lab Canc Prevent, SAIC Frederick, Frederick, MD 21702 USA.;muegge@ncifcrf.gov
    1. Year: 2007
    2. Date: Sep
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 104
    2. 36
    3. Pages: 14366-14371
  4. Type of Article: Article
  5. ISSN: 0027-8424
  1. Abstract:

    Polycomb-mediated repression and DNA methylation are important epigenetic mechanisms of gene silencing. Recent evidence suggests a functional link between the polycomb repressive complex (PRC) and Dnmts in cancer cells. Here we provide evidence that Lsh, a regulator of DNA methylation, is also involved in normal control of PRC-mediated silencing during embryogenesis. We demonstrate that Lsh, a SNF2 homolog, can associate with some Hox genes and regulates Dnmt3b binding, DNA methylation, and silencing of Hox genes during development. Moreover, Lsh can associate with PRO components and influence PRC-mediated histone modifications. Thus Lsh is part of a physiological feedback loop that reinforces DNA methylation and silencing of PRC targets.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000249333600035

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