Skip NavigationSkip to Content
Return Return to Search Results

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR

  1. Author:
    Park, J. H.
    Adoro, S.
    Lucas, P. J.
    Sarafova, S. D.
    Alag, A. S.
    Doan, L. L.
    Erman, B.
    Liu, X. L.
    Ellmeier, W.
    Bosselut, R.
    Feigenbaum, L.
    Singer, A.

  2. Author Address

    NCI, NIH, Expt Immunol Branch, Bethesda, MD 20892 USA. Univ Penn, Immunol Grad Grp, Philadelphia, PA 19104 USA. NCI, NIH, Expt Transplant & Immunol Branch, Bethesda, MD 20892 USA. Sabanci Univ, Fac Engn & Nat Sci, Biol Sci & Bioengn Program, Istanbul, Turkey. NCI, NIH, Immunol Cell Biol Branch, Bethesda, MD 20892 USA. Med Univ Veinna, Inst Immunol, Vienna, Austria. Canc Res & Dev Ctr, NCI, SAIC, Ft Detrick, MD 21702 USA. Davidson Coll, Dept Biol, Davidson, NC 28035 USA.;Singer, A, NCI, NIH, Expt Immunol Branch, Bethesda, MD 20892 USA.;singera@njh.gov
    1. Year: 2007
    2. Date: Oct
  2. Journal: Nature Immunology
    1. 8
    2. 10
    3. Pages: 1049-1059
  4. Type of Article: Article
  5. ISSN: 1529-2908
  1. Abstract:

    T cell immunity requires the long-term survival of T cells that are capable of recognizing self antigens but are not overtly autoreactive. How this balance is achieved remains incompletely understood. Here we identify a homeostatic mechanism that transcriptionally tailors CD8 coreceptor expression in individual CD8+ T cells to the self-specificity of their clonotypic T cell receptor (TCR). 'Coreceptor tuning' results from interplay between cytokine and TCR signals, such that signals from interleukin 7 and other common gamma-chain cytokines transcriptionally increase CD8 expression and thereby promote TCR engagement of self ligands, whereas TCR signals impair common gamma-chain cytokine signaling and thereby decrease CD8 expression. This dynamic interplay induces individual CD8+ T cells to express CD8 in quantities appropriate for the self-specificity of their TCR, promoting the engagement of self ligands, yet avoiding autoreactivity.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1038/ni1512
  3. View record in Web of Science®
  4. WOS: 000249691400019

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel