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Preparation of orthogonally-protected 3-methoxy-4-phosphonomethyl-L-phenylalanine, a new reagent for the synthesis of phosphotyrosyl mimetic-containing peptides

  1. Author:
    Choi, W. J.
    Xang, S. U.
    Burke, T. R.

  2. Author Address

    NCI, Frederick Canc Res & Dev Ctr, Natl Inst Hlth, Med Chem Lab, Frederick, MD 21702 USA.;Burke, TR, NCI, Frederick Canc Res & Dev Ctr, Natl Inst Hlth, Med Chem Lab, Bldg 376 Boyles St, Frederick, MD 21702 USA.;tburke@helix.nih.gov
    1. Year: 2007
    2. Date: Sep
  2. Journal: Letters in Organic Chemistry
    1. 4
    2. 6
    3. Pages: 433-439
  4. Type of Article: Article
  5. ISSN: 1570-1786
  1. Abstract:

    [(4-Hydroxymethyl-2-methoxyphenyl)methyl]phosphonic acid di-tert-butyl ester (8) served as a key intermediate in the stereoselective preparation of N-Fmoc-3-methoxy-4-(di-tert-butyl)phosphonomethyl-L-phenylalanine (5). Reagent 5 may be useful for the solid-phase synthesis of phosphotyrosyl mimetic-containing peptides.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000249867000011

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