Skip NavigationSkip to Content
Return Return to Search Results

Human immunodeficiency virus type 1 derivative with 7% simian immunodeficiency virus genetic content is able to establish infections in pig-tailed macaques

  1. Author:
    Igarashi, T.
    Iyengar, R.
    Byrum, R. A.
    Buckler-White, A.
    Dewar, R. L.
    Buckler, C. E.
    Lane, H. C.
    Kamada, K.
    Adachi, A.
    Martin, M. A.

  2. Author Address

    NIH, NIAID, Mol Microbiol Lab, Bethesda, MD 20892 USA. Bioqual, Rockville, MD 20850 USA. Sci Applicat Int Corp, Frederick Inc, Frederick, MD 21702 USA. NCI, NIAID, Immunoregulat Lab, Bethesda, MD 20892 USA. Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Virol, Tokushima 770, Japan.;Martin, MA, NIH, NIAID, Mol Microbiol Lab, Bldg 4,Room 315,4 Ctr Dr, Bethesda, MD 20892 USA.;malm@nih.gov
    1. Year: 2007
    2. Date: Oct
  2. Journal: Journal of Virology
    1. 81
    2. 20
    3. Pages: 11549-11552
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    A human immunodeficiency virus type 1 (HIV-1) derivative (HIVNL-DT5R) containing sequences encoding a 7-amino-acid segment of CA and the entire vif gene from simian immunodeficiency virus (SIV) was previously shown to establish spreading infections in cultured macaque peripheral blood mononuclear cells. To assess its replicative and disease-inducing properties in vivo, HIVNL-DT5R was inoculated into pig-tailed macaques. HIVNL-DT5R generated plasma viremia in all five of the monkeys and elicited humoral responses against all of the HfV-1 structural proteins but did not cause CD4(+) T-lymphocyte depletion or clinical disease. Additional adaptation will be required to optimize infectivity in vivo.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1128/jvi.00960-07
  3. View record in Web of Science®
  4. WOS: 000250019400070

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel