Skip NavigationSkip to Content
Return Return to Search Results

IL-1alpha increases serum leptin concentrations in man

  1. Author:
    Janik, J. E.
    Curti, B. D.
    Gause, B. L.
    Kopp, W. C.
    1. Year of Conference: 1997
  2. Conference Name: Annual Meeting of the American Association for Cancer Research
    1. 16
    2. Pages: A371
  4. Type of Work: Meeting Abstract
  1. Abstract:

    Leptin, the protein product of the ob gene, regulates appetite and body weight. Animals with mutations in the ob gene are obese and lose weight with administration of recombinant leptin. Normal animals also lose weight in response to leptin administration. Leptin can be measured in human serum and its concentration correlates with the percentage of body fat and body mass index. Endotoxin and cytokines induced by endotoxin, IL-1 and TNF, increase expression of leptin in hamsters. We hypothesized that serum leptin levels might be elevated by cytokine treatment and produce weight loss by causing a reduction in appetite or an increase in metabolism. Serum leptin concentrations were measured in patients with cancer before and after administration of recombinant human IL-1alpha. Fourteen patients received IL-1alpha at one of three dose levels, 0.03, 0.1 or 0.3 ug/kg/day, for five days. Serum leptin concentrations increased in all but one patient within 24 hours after the first dose. The increase in leptin was directly correlated with IL-1alpha dose (p=0.0030). Despite continued administration of IL-1alpha, by the final day of treatment serum leptin concentrations had returned to pretreatment levels. Anorexia induced by IL-1alpha may be due to this early elevation in serum leptin concentration, but continued exposure to IL-1alpha produced tachyphylaxis in the leptin response. (C) American Society of Clinical Oncology 1997

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel