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HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis

  1. Author:
    Bokesch, H. R.
    Wamiru, A.
    Le Grice, S.
    Beutler, J. A.
    Mckee, T. C.
    McMahon, J. B.

  2. Author Address

    Bokesch, Heidi R.; Wamiru, Antony, Beutler, John A.; McKee, Tawnya C.; McMahon, James B.] NCI, Mol Targets Dev Program, Frederick, MD 21702 USA. [Bokesch, Heidi R.; Wamiru, Antony] NCI, SAIC Frederick Inc, Frederick, MD 21702 USA. [Le Grice, Stuart F. J.] NCI, HIV Drug Resistance Program, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Journal of Natural Products
    1. 71
    2. 9
    3. Pages: 1634-1636
  4. Type of Article: Article
  1. Abstract:

    Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in vitro with IC50 values of 1.46, > 18, and 1.19 mu M, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1(RT), none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 mu g/mL).

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External Sources

  1. PMID: 18763827

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