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Cell-Permeable Esters of Diazeniumdiolate-Based Nitric Oxide Prodrugs

  1. Author:
    Chakrapani, H.
    Maciag, A. E.
    Citro, M. L.
    Keefer, L. K.
    Saavedra, J. E.

  2. Author Address

    Chakrapani, Harinath, Keefer, Larry K.] NCI, Chem Sect, Comparat Carcinogenesis Lab, Frederick, MD 21702 USA. [Maciag, Anna E.; Citro, Michael L.; Saavedra, Joseph E.] NCI, Basic Res Program, SAIC Frederick, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Organic Letters
    1. 10
    2. 22
    3. Pages: 5155-5158
  4. Type of Article: Article
  1. Abstract:

    Although O-2-(2,4-dinitrophenyl) derivatives of diazeniumdiolate-based nitric oxide (NO) prodrugs bearing a free carboxylic acid group were activated by glutathione to release NO, these compounds were poor sources of intracellular NO and showed diminished anti pro I iterative activity against human leukemia HL-60 cells. The carboxylic acid esters of these prodrugs, however, were found to be superior sources of intracellular NO and potent inhibitors of HL-60 cell proliferation.

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External Sources

  1. PMID: 18956868

Library Notes

  1. No notes added.
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