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Detection of nonnucleoside reverse-transcriptase inhibitor-resistant HIV-1 after discontinuation of virologically suppressive antiretroviral therapy

  1. Author:
    Hare, C. B.
    Mellors, J.
    Krambrink, A.
    Su, Z. H.
    Skiest, D.
    Margolis, D. M.
    Patel, S. S.
    Barnas, D.
    Frenkel, L.
    Coombs, R. W.
    Aweeka, F.
    Morse, G. D.
    Haas, D. W.
    Boltz, V.
    Palmer, S.
    Coffin, J.
    Havlir, D. V.

  2. Author Address

    Hare, C. Bradley] Univ Calif San Francisco, Dept Med, San Francisco Gen Hosp, San Francisco, CA 94110 USA. [Mellors, John, Patel, Sheran S.; Barnas, Douglas] Univ Pittsburgh, Pittsburgh, PA USA. [Krambrink, Amy, Su, Zhaohui] Harvard Univ, Sch Publ Hlth, Stat & Data Anal Ctr, Boston, MA 02115 USA. [Skiest, Daniel] Baystate Med Ctr, Springfield, MA USA. [Margolis, David M.] Univ N Carolina, Chapel Hill, NC USA. [Frenkel, Lisa, Coombs, Robert W.] Univ Washington, Seattle, WA 98195 USA. [Morse, Gene D.] SUNY Buffalo, Buffalo, NY 14260 USA. [Haas, David W.] Vanderbilt Univ, Nashville, TN USA. [Boltz, Valerie, Palmer, Sarah, Coffin, John] NCI, HIV Drug Resistance Program, Frederick, MD 21701 USA.
    1. Year: 2008
  2. Journal: Clinical Infectious Diseases
    1. 47
    2. 3
    3. Pages: 421-424
  4. Type of Article: Article
  1. Abstract:

    Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400 copies/mL and <= 50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.

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External Sources

  1. PMID: 18558886

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