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Contribution of CD8(+) T cells to containment of viral replication and emergence of mutations in Mamu-A*01-restricted epitopes in simian immunodeficiency virus-infected rhesus monkeys

  1. Author:
    Kim, E. Y.
    Veazey, R. S.
    Zahn, R.
    McEvers, K. J.
    Baumeister, S.
    Foster, G. J.
    Rett, M. D.
    Newberg, M. H.
    Kuroda, M. J.
    Rieber, E. P.
    Piatak, M.
    Lifson, J. D.
    Letvin, N. L.
    Wolinsky, S. M.
    Schmitz, J. E.

  2. Author Address

    Kim, Eun-Young, Wolinsky, Steven M.] Northwestern Univ, Div Infect Dis, Feinberg Sch Med, Chicago, IL 60611 USA. [Veazey, Ronald S.; Kuroda, Marcelo J.] Tulane Natl Primate Res Ctr, Covington, LA 70433 USA. [Zahn, Roland, McEvers, Kimberly J.; Baumeister, Susanne H. C.; Foster, Gabriel J.; Rett, Melisa D.; Newberg, Michael H.; Letvin, Norman L.; Schmitz, Joern E.] Beth Israel Deaconess Med Ctr, Div Viral Pathogenesis, Boston, MA 02115 USA. [Rieber, E. Peter] Tech Univ Dresden, Inst Immunol, D-01101 Dresden, Germany. [Piatak, Michael, Jr.; Lifson, Jeffrey D.] NCI, AIDD Vaccine Program, SAIC Fredrick Inc, Frederick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Journal of Virology
    1. 82
    2. 11
    3. Pages: 5631-5635
  4. Type of Article: Article
  1. Abstract:

    Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with compensatory changes outside of the epitope. Eliminating CD8(+) lymphocytes from rhesus monkeys during primary infection resulted in more rapid disease progression that was associated with preservation of canonical epitopes. These results confirm the importance of cytotoxic T cells in controlling viremia and the constraint on epitope sequences that require compensatory changes to go to fixation.

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External Sources

  1. PMID: 18367519

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