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Myosin-Va mediates RNA distribution in primary fibroblasts from multiple organs

  1. Author:
    Salerno, V. P.
    Calliari, A.
    Provance, D. W.
    Sotelo-Silveira, J. R.
    Sotelo, J. R.
    Mercer, J. A.

  2. Author Address

    Salerno, Veronica P.; Provance, D. William, Jr.; Mercer, John A.] McLaughlin Res Inst, Great Falls, MT 59405 USA. [Salerno, Veronica P.] Univ Fed Rio de Janeiro, EEFD, Dept Biociencias Atividade Fis, BR-21941 Rio De Janeiro, Brazil. [Calliari, Aldo, Sotelo-Silveira, Jose R.; Sotelo, Jose R.] Inst Invest Biol Clemente Estable, Dept Prot & Acidos Nucl, Montevideo, Uruguay. [Calliari, Aldo] Univ Republica, Fac Vet, Dept Biol Celular & Mol, Montevideo, Uruguay. [Sotelo-Silveira, Jose R.] NCI, SAIC Frederick Inc, Lab Mol Technol, Frederick, MD 21701 USA.
    1. Year: 2008
  2. Journal: Cell Motility and the Cytoskeleton
    1. 65
    2. 5
    3. Pages: 422-433
  4. Type of Article: Article
  1. Abstract:

    Myosin-Va has been shown to have multiple functions in a variety of cell types, including a role in RNA transport in neurons. Using primary cultures of cells from organs of young dilute-lethal (Myo5a(d-l)/Myo5a(d-l)) null mutant mice and wild-type controls, we show that in some, but not all, tissues, RNA distribution is dramatically different in the homozygous null mutant cells. The dependence of RNA localization on myosin-Va correlates with the relative abundance of the brain-specific splicing pattern of the myosin-Va tail. We also show that myosin-Va is involved in RNA localization soon after synthesis, because the effects of its absence are diminished for RNAs that are more than 30 min old. Finally, we show that localization of P-actin mRNA is significantly changed by the absence of myosin-Va. These results suggest that myosin-Va is involved in a transient transport or tethering function in the perinuclear region. Cell Motil.

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External Sources

  1. PMID: 18357619

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