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Tissue-based research in kidney cancer: Current challenges and future directions

  1. Author:
    Signoretti, S.
    Bratslavsky, G.
    Waldman, F. M.
    Reuter, V. E.
    Haaga, J.
    Merino, M.
    Thomas, G. V.
    Pins, M. R.
    Libermann, T.
    Gillespie, J.
    Tomaszewski, J. E.
    Compton, C. C.
    Hruszkewycz, A.
    Linehan, W. M.
    Atkins, M. B.

  2. Author Address

    Signoretti, Sabina] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA. [Signoretti, Sabina] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA. [Libermann, Towia] BIDMC Genom Ctr, Boston, MA USA. [Atkins, Michael B.] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Hematol Oncol, Boston, MA 02215 USA. [Bratslavsky, Gennady, Linehan, W. Marston] NCI, Urol Oncol Branch, Ctr Canc Res, Bethesda, MD 20892 USA. [Merino, Maria] NCI, Pathol Lab, Bethesda, MD 20892 USA. [Compton, Carolyn C.] NCI, Off Biorepositories & Biospecimen Res, Bethesda, MD 20892 USA. [Waldman, Frederick M.] Univ Calif San Francisco, Dept Lab Med, Ctr Comprehens Canc, San Francisco, CA 94143 USA. [Waldman, Frederick M.] Univ Calif San Francisco, Dept Urol, Ctr Comprehens Canc, San Francisco, CA 94143 USA. [Reuter, Victor E.] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA. [Haaga, John] Univ Hosp Cleveland, Dept Radiol, Cleveland, OH 44106 USA. [Haaga, John] Case Western Reserve Univ, Sch Med, Cleveland, OH USA. [Thomas, George V.] Univ Calif Los Angeles, Dept Pathol, Los Angeles, CA 90024 USA. [Pins, Michael R.] Advocate Lutheran Gen Hosp, Dept Pathol, Park Ridge, IL USA. [Gillespie, John] NCI, Sci Applicat Int Corp Frederick Inc, Frederick, MD 21701 USA. [Tomaszewski, Joseph E.] NCI, Div Canc Treatment & Diag, Rockville, MD USA. [Hruszkewycz, Andrew] NCI, Organ Syst Branch, Rockville, MD USA.
    1. Year: 2008
  2. Journal: Clinical Cancer Research
    1. 14
    2. 12
    3. Pages: 3699-3705
  4. Type of Article: Review
  1. Abstract:

    The past several years have seen unprecedented advances in the application of various therapeutic strategies for the treatment of patients with renal cancer. The availability of active immunotherapy, antiangiogenic therapy, and targeted therapy for this disease has brought front and center issues related to choosing the appropriate treatment for particular patient populations. It is increasingly evident that the most promising treatment selection strategies will incorporate identifying specific features of the tumor itself. To facilitate this move toward personalized medicine, it is critically important to establish some standard principles for renal cancer tissue collection, preparation, and analysis for translational research studies. In this article, we identify and discuss some critical issues related to tissue-based kidney cancer research. We focus on five major areas as follows: (a) surgical and image-guided techniques for tissue collection, (b) quality control of specimen collection, processing, storage, and review, (c) issues related to analysis of paraffin embedded tissues, (d) genomic studies, and (e) assessment of reproducibility of assays across institutions. In addition, some practical implementation strategies are proposed. Although many of the topics discussed are specific for renal cancer, several are also relevant to tissue based biomarker investigations in a broad array of malignancies.

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External Sources

  1. PMID: 18559586

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