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Targeting prostate cancer stem cells

  1. Author:
    Crea, F.
    Mathews, L. A.
    Farrar, W. L.
    Hurt, E. M.

  2. Author Address

    Cancer Stem Cell Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, Maryland, USA.
    1. Year: 2009
    2. Date: Dec
    3. Epub Date: 11/21/2009
  2. Journal: Anti-cancer agents in medicinal chemistry
    1. 9
    2. 10
    3. Pages: 1105-13
  4. Type of Article: Review
  5. ISSN: 1875-5992 (Electronic);1871-5206 (Linking)
  1. Abstract:

    Cancer stem cells are the sub-population of cells present within tumors responsible for tumorigenesis. These cells have unique biological properties including self-renewal and the ability to differentiate. Furthermore, it is thought that these cells are more resistant to conventional chemotherapy and, as a result, are responsible for patient relapse. We will discuss the identification of prostate cancer stem cells, their unique properties and how these cells may be targeted for more efficacious therapies.

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  1. Keywords:

External Sources

  1. PMID: 19925394

Library Notes

  1. Fiscal Year: FY2009-2010

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