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Korundamine a, a Novel Hiv-Inhibitory and Antimalarial Hybrid Naphthylisoquinoline Alkaloid Heterodimer From Ancistrocladus Korupensis

  1. Author:
    Hallock, Y. F.
    Cardellina, J. H.
    Schaffer, M.
    Bringmann, G.
    Francois, G.
    Boyd, M. R.
    1. Year: 1998
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 8
    2. 13
    3. Pages: 1729-1734
  4. Type of Article: Article
  1. Abstract:

    A unique heterodimeric naphthylisoquinoline alkaloid, korundamine A (2), comprised of two different monomeric biaryl halves, has been isolated from the Cameroonian tropical liana Ancistrocladus korupensis. Korundamine A is the first ''hybrid'' dimer found in the Ancistrocladaceae; rr! vitro, it demonstrated anticytopathic activity against HIV-1 and antimalarial activity against Plasmodium falciparum. Published by Elsevier Science Ltd. [References: 20]

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